Pioneering
nonequilibrium imaging of membrane proteins
to accelerate
breakthrough therapeutics.

Nonequilibrium
imaging
is:
different
controlled
spontaneous
dynamic
simple
fast
precise
reliable
low-cost
different
It's a new transformative science with the potential to achieve results in minutes, not months.

The nonequilibrium imaging revolution:
solving membrane protein structures
rapidly and reliably
to save lives.

NOVATARG has pioneered a novel nonequilibrium imaging approach to solve the structures of difficult membrane proteins involved in a wide range of serious and life-threatening diseases, including cancer, diabetes, autoimmune, cardiovascular and neurodegenerative diseases, psychiatric disorders, as well as infectious diseases like HIV/AIDS and COVID-19.

We are working to drastically improve the speed at which membrane protein targets and therapeutics are identified, the specificity of target engagement, and the cost of identifying and developing clinical candidates.

NOVATARG’s nonequilibrium imaging approach holds potential to fundamentally shift the current landscape of therapeutic development. It aims to address crucial unmet needs in modern membrane protein structure-based drug design (SBDD) by -for innovative targeted biomedicines and therapeutics.

Six of the ten world best-selling drugs target a membrane protein!

Membrane proteins are the largest class of drug targets. The market for drugs targeting membrane proteins is estimated to exceed 1 trillion U.S. dollars.

However, the lack of solubility of membrane proteins in water together with their dependence on lipids has imposed critical bottlenecks to characterization of the structures of membrane proteins, which is indispensable to modern structure-based drug design (SBDD) efforts. Conventional solution-based techniques often fail, or produce unreliable, inconsistent, or insufficient structural information for membrane proteins.

NOVATARG holds licenses to patented technologies demonstrating the company’s unique potential to streamline biomedical research and drug discovery advancements.

Top ten drugs global sales 2023 (U.S. $ billions)
Chart showing sales figures of top pharmaceutical drugs.
© Copyright 2024 NOVATARG Theranostics, may not be reproduced or distributed without prior consent from the author, Fatemeh Mojtabai, PhD.
Drug sales data source: Top companies and drugs by sales in 2023. Nature Review Drug Discovery, March 2024.

Excerpts from peer reviews

“Technologies providing crystals of membrane proteins are very valuable for academia and industry, especially for the pharmaceutical industry, since membrane proteins are the major drug targets. Thus, development of these technologies are of highest interest, especially if they are expected to be rapid and low-cost”
“The technique would provide a novel and significant contribution to accessing biological crystalline structures in an easy biologically relevant environment”.
“If successful, this approach would open the horizon to a new and generalized approach to obtaining crystals for membrane proteins and further structure determination”.
“There is significant general interest in obtaining structural information from membrane proteins. Existing methodology is insufficient and, if successful, this approach could be widely adopted for studying this important protein class”.